153 Molecular pathogenesis by HTLV-1 bZIP factor
نویسندگان
چکیده
منابع مشابه
HTLV-1 bZIP factor gene: Its roles in HTLV-1 pathogenesis.
The HTLV-1 bZIP factor (HBZ) gene is transcribed as an anti-sense transcript of HTLV-1 from the 3' long terminal repeat (LTR). Recent studies showed that the HBZ gene was expressed in all ATL cases, suggesting its critical role in leukemogenesis. In addition, only the HBZ gene sequence remains intact, unaffected by nonsense mutations and deletion. HBZ mRNA promotes proliferation of adult T-cell...
متن کاملHTLV-1 bZIP Factor Induces Inflammation through Labile Foxp3 Expression
Human T-cell leukemia virus type 1 (HTLV-1) causes both a neoplastic disease and inflammatory diseases, including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 basic leucine zipper factor (HBZ) gene is encoded in the minus strand of the proviral DNA and is constitutively expressed in infected cells and ATL cells. HBZ increases the number of regulatory T (Treg) ...
متن کاملMolecular and Cellular Pathobiology HTLV-1 bZIP Factor Suppresses Apoptosis by Attenuating the Function of FoxO3a and Altering Its Localization
As the infectious agent causing human adult T-cell leukemia (ATL), the human T-cell leukemia virus type 1 (HTLV-1) virus spreads in vivo primarily by cell-to-cell transmission. However, the factors that determine its transmission efficiency are not fully understood. The viral genome encodes the HTLV-1 bZIP factor (HBZ), which is expressed in all ATL cases and is known to promote T-cell prolifer...
متن کاملHTLV-1 bZIP factor HBZ promotes cell proliferation and genetic instability by activating OncomiRs.
Viruses disrupt the host cell microRNA (miRNA) network to facilitate their replication. Human T-cell leukemia virus type I (HTLV-1) replication relies on the clonal expansion of its host CD4(+) and CD8(+) T cells, yet this virus causes adult T-cell leukemia/lymphoma (ATLL) that typically has a CD4(+) phenotype. The viral oncoprotein Tax, which is rarely expressed in ATLL cells, has long been re...
متن کاملHTLV-1 bZIP factor suppresses apoptosis by attenuating the function of FoxO3a and altering its localization.
As the infectious agent causing human adult T-cell leukemia (ATL), the human T-cell leukemia virus type 1 (HTLV-1) virus spreads in vivo primarily by cell-to-cell transmission. However, the factors that determine its transmission efficiency are not fully understood. The viral genome encodes the HTLV-1 bZIP factor (HBZ), which is expressed in all ATL cases and is known to promote T-cell prolifer...
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ژورنال
عنوان ژورنال: JAIDS Journal of Acquired Immune Deficiency Syndromes
سال: 2014
ISSN: 1525-4135
DOI: 10.1097/01.qai.0000446737.31074.43